Word: somatostatin
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...biochemistry professor at the University of California at San Francisco and a pioneer in recombinant DNA, and Robert Swanson, a financier who finds backers for new companies. Almost immediately, the firm began announcing a series of breakthroughs. The first, in 1977, was the production of a brain hormone called somatostatin, which may be used to treat certain hormonal disorders. In 1979 the company developed thymosin alpha1, which is now being tested by the National Cancer Institute for possible treatment of certain types of brain and lung cancer. Genentech's gross revenues have risen from...
...those applications - the recombinant DNA technique - has begun to fulfill its widely her alded promise. By inserting genes into the DNA of a laboratory strain of the common intestinal bacterium E. coli, re searchers have induced the little bug to produce somatostatin, a mammalian brain hormone. Last month the bacterium manufactured synthetic human insulin, raising hopes that the hormone vital to the well-being of the world's diabetics may some day soon be available in virtually unlimited supply...
Those benefits were dramatically demonstrated last fall when California scientists inserted into the DNA of E. coli bacteria synthesized copies of a gene that orders the production of somatostatin, a vital brain hormone in mammals. Researchers who first isolated that hormone needed nearly half a million sheep brains to produce 5 mg (.00018 oz.) of the substance. But the California scientists used only about 8 liters (2 gal.) of a culture containing their re-engineered bacteria to obtain the same amount...
...insulin. In the work announced last week, Microbiologist Herbert Boyer of the University of California, San Francisco, along with Biochemist Arthur Riggs of the City of Hope Medical Center near Los Angeles and Physiologist Wylie Vale of the Salk Institute in San Diego synthesized copies of the gene for somatostatin, a hormone in the brains of mammals that inhibits the secretion of pituitary growth hormone. Then they chemically inserted the genes into the DNA of E. coli bacteria, which multiplied and began manufacturing somatostatin...
...researchers who first isolated somatostatin needed nearly half a million sheep brains to produce 5 mg. (.00018 oz.) of the substance. Using their recombinant DNA technique, the California researchers required only 2 gal. of bacterial culture to obtain the same amount...
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