Word: spanned
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Dates: during 1990-1999
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...study group this semester. This demagogue Reed, whose unctuous invective against "moral decay" was the embodiment of religious hypocrisy, whose appropriation of the Kennedys' rhetoric served only to undermine their name and that of the school, was welcomed by the K-School establishment in order to promote (over C-SPAN) its spanking new conservative image. Forum director Campion comments, "I think what you're seeing is a very real conservative effort on the part of the K-School to present views from all across the political spectrum...
...associated with a dramatic reduction in cancer or other diseases; in others, some antioxidants, such as beta-carotene, actually seem to be associated with an increase. In either event, few contemporary aging researchers think self-medicating at a salad bar is the best way to extend the human life-span. Far more promising might be new research into another by-product of cellular metabolism: glycosylation--or what cooks call browning...
Roth finds this frustrating. "I think caloric restriction could take us beyond a life-span of 80," he says, "maybe even 120. After all, you rarely see a fat centenarian." Given modern dietary habits, however, it may be more practical to find out what part of the metabolic system caloric restriction operates on and then imitate that effect pharmacologically. "Essentially," explains Roth, "we'd use a pill to trick a cell into thinking less food is coming...
Since telomerase keeps these tenacious cells going, is it reasonable to assume that the same enzyme could be used artificially to help mortal cells--and the body itself--exceed their programmed life-span? At Geron Corp., a San Francisco-based biomedical firm, biologist Calvin Harley is trying to find out. Harley, who collaborated with Greider on her later telomere work, is looking for the genes that direct telomerase production, believing he might be able to manipulate them so that the spigot for the enzyme can be turned on and off at will. "I think we are going to see fundamental...
...Harley begins his search, other genes implicated in aging have already been flushed out of hiding. At McGill University, Hekimi's long-lived nematodes have helped expose a few of them. Hekimi created his little uberworms by crossing and recrossing individuals that lived longer naturally, slowly extending the life-spans of later generations. He then searched the animals' chromosomes until he found the mutated gene responsible, a gene he dubbed Clock-1. "The Clock-1 gene is critical in setting life-span," Hekimi says. "More important, with cloning and genetic mapping, we were able to determine just which protein...