Word: spinal
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Dates: during 2000-2009
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...dichotomy of an upbeat 50s pop tune with distorted guitar and crackling vocals. “Old Man” begins with a heavy reliance on a dreary guitar and keyboard dirge. The first half presents an anthemic quality that would have been fitting in such rock-parodies as Spinal Tap; yet halfway through the song, the chorus takes a cheery psychedelic turn. The album’s most unexpected success, “The Drop I Hold,” features Alexander sing-speaking over a lazy quasi-hip-hop guitar riff. The mix of the eerie synthesizer...
...likely to have an infant with spina bifida, nearly twice as likely to have a baby with other neural-tube defects, and more vulnerable to giving birth to babies with heart problems, cleft palate or cleft lip, abnormal rectum or anus development, and hydrocephaly, a condition in which excess spinal fluid builds up in the brain. While the risk of birth defects in obese women has been known, "I wouldn't have predicted the range of birth defects found to be increased when we looked at maternal obesity," says Judith Rankin, an epidemiologist and one of the authors...
...cousins, cells taken from mature organs or skin that were limited to becoming only specific types of tissue. On Jan. 23, after nearly a decade of preparation, the Food and Drug Administration approved the first trial of an embryonic- stem-cell therapy for a handful of patients paralyzed by spinal-cord injuries...
...trial will enroll patients with injury to the thoracic region, high in the spinal cord between the third and 10th vertebrae. Doctors will be trained to inject the cell treatment at specific locations, where the cells will remain to do their nerve-nurturing work. "I think it's incredibly exciting," says Dr. Susan Fisher, a stem-cell scientist and a professor of obstetrics, gynecology and reproductive science at University of California, San Francisco. "This really provides a blueprint for how to do these sorts of trials. It really proves the principle that these sorts of human embryonic-stem-cell therapies...
...than a dozen patients and is not designed to test the effectiveness of the cells. Rather, it will simply monitor the safety of inserting them into people. The researchers will be looking for whether the cells cause tumors, trigger an immune response or start to migrate away from the spinal-cord area. "There are certainly unknowns that we can't predict," says Dr. David Scadden, co-director of the Harvard Stem Cell Institute. "We don't know whether or not these cells might grow abnormally in a person. We don't know if things might occur just by these cells...