Word: spleened
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Norman and his associates--among whom is Dr. Victor C. Covelli, Research Fellow in Surgery--earlier discovered the crucial role of the spleen in producing Factor VIII, a substance whose presence in the body prevents hemophilia...
...Healthy Spleen...
...reduce the stomach's output of digestive acids. But these measures, plus massive transfusions, failed to halt the bleeding, and Kasperak was soon back in surgery. In another 21-hour operation, the surgeons tried to stanch the bleeding from an ulcer high in his stomach, and removed his spleen in the hope of improving the clotting quality of his blood. But to no avail: this week Kasperak died...
...known that the spleen is somehow involved in the production of AHF, but just how is not yet clear. Experimenting with pigs, the Boston City Hospital surgeons found that a normal spleen begins to produce more AHF when perfused with the blood of a hemophiliac. To one of the surgeons, Dr. John C. Norman, this suggests the possibility of transplanting a normal spleen into a hemophiliac, so that his abnormal blood might stimulate the new spleen into plentiful production...
Surgically, such an operation would be far simpler than transplanting a heart, liver or even a kidney. But Dr. Norman emphasized that further experimentation-with dogs-must be conducted before spleen transplantation is attempted on a human being. Then, in all probability, a donor's spleen will be enclosed in a plastic bag, hooked up to a hemophiliac's circulating system and hung externally on his arm until it is certain that the method works...