Word: spleening
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What Norman found is that Factor VIII is produced by the spleen. In the past the treatment for hemophilia has been the injection of Factor VIII into the hemophiliac. Te new method is to replace the defective spleen of the hemophiliac with a healthy...
...Most important, the hemophiliac tends to produce antibodies which counteract the vital Factor VIII when it is injected. With the new techniques of organ transplant that have recently been developed, it is possible to establish a permanent source of Factor VIII inside the hemophiliac--by inserting an entirely new spleen...
...spleen transplant of the dog Ellie is the first totally successful one done by Norman's project. In the past, problems have arisen because the hemophiliac dog rejected the new spleen. Rejection occurs when an animal refuses to accept living tissue from another body. In Ellie's case, doctors avoided the threat of rejection with a combination of immunosuppressors: cortisone, actinomycin C, imuran, and antilymphocyte serum...
...experimental success with Ellie is a prelude to a trial with a human hemophiliac. In most cases the plan is for a normal mother to donate her spleen--which is not usually a vital organ--to her hemophiliac son. The close genetic relationship between mother and son would minimize the difficulty of the transplant...
...risk of the spleen transplant operation is minimal--the same risk that there is in a regular spleen removal, from zero to one per cent...