Word: staging
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Until now, research has generally concentrated on keeping HSV1 inactive - and preventing cold sores from ever showing up. But the Duke researchers took the opposite tack: figuring out precisely how to switch the virus from latency to its active stage. That's important, says lead author Dr. Bryan Cullen, professor of molecular genetics and microbiology at Duke, "because unless you activate the virus, you can't kill...
Cullen and his team were able to replicate the intricate process using lab mice. They started by identifying the tiniest components of the HSV-1 strain. In its latent stage, HSV-1 produces a single molecular product, called latency-associated transcript RNA, or LAT RNA. Unlike most messenger RNA, LAT RNA doesn't produce proteins, so scientists have never been able to determine LAT RNA's exact function. But by inserting the LAT RNA into mice, Cullen found that it breaks down into even smaller strands called microRNA. Researchers then discovered that it was the microRNA that blocked production...
...factors that fertility specialists consider when helping couples conceive, the Stanford researchers whittled down the list to the four most powerful predictors of an IVF pregnancy: the total number of embryos that a couple produces during a cycle, the number of embryos that survive to the eight-cell stage, the percentage of embryos that stop dividing and a woman's level of the follicle-stimulating hormone. What surprised the study's authors was that these measures appeared to be more relevant to establishing a pregnancy than embryo quality - that is, how many of a couple's "good" embryos are transplanted...
...absolutely tired and sick and tired of being forced to go to the polls and say I'm going to make this choice between the lesser of two evils," the Colorado congressman said at an October debate in Michigan, standing across the stage from his ideological opponent, John McCain, who supports a pathway to citizenship for illegal immigrants. "I really don't intend to do that again...
...somewhat mixed message of his own. He continued to favor all the parts of his comprehensive plan - border security, increased employer sanctions for illegal hiring and a path to citizenship for the undocumented - but he mostly refrained from using the word "comprehensive." Instead, he spoke of a two-stage solution. First, he would secure the borders, a process that would be certified by border state governors. Then he would push for a process to allow the 12 million undocumented immigrants to become full citizens...