Word: staphylococci
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...pharmaceutical companies have begun to comb through the vast chemical libraries assembled over the past decade in search of new antimicrobial agents. The effort is starting to pay off. Since September 1999, the U.S. Food and Drug Administration has approved two new antibiotics that target both the enterococci and staphylococci. One--linezolid--seems particularly promising; it represents the first new class of antibiotics to come on the market in 35 years...
Both daptomycin and linezolid (branded under the trade names Cidecin and Zyvox) are aimed at drug-resistant enterococci and staphylococci, which have ballooned into a huge problem for nursing homes and hospitals. But while that is the most attractive commercial market, a number of American pharmaceutical companies are also participating in private-public partnerships aimed at resolving the global health crisis created by drug-resistant malaria and TB. At present, neither disease is a tremendous problem in the U.S. or Western Europe, but that happy situation may not last forever, especially where TB is concerned. In 1992, at the height...
...breed with one another, creating increasingly resistant germs. Pharmaceutical companies are racing to create new antibiotics that can replace vancomycin as the drug of last recourse. The leading candidate: Synercid, an experimental drug being developed by Rhone-Poulenc Rorer. Tests show that it should defeat even vancomycin-resistant staphylococci--at least until a tougher strain of bacteria evolves...
...laboratory workbench while he was on vacation. He noticed that one of the plates contained a blob of moldy contaminant that had apparently grown from particles wafting in through an open window. Having settled on the jellylike nutriment intended for the cultivation of a type of bacteria called staphylococci, the fungus had grown into a flourishing mass...
...studied the plate, Fleming noticed that the colonies of staphylococci around the edge of the gloppy mold had been destroyed. This observation set the scientist off on a series of experiments in which he demonstrated that the mysterious mold was able to kill off an entire range of disease-producing bacteria. Because this particular fungus was a member of the Penicillium group, he named it penicillin after its presumed active ingredient...