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...leading theory to explain this fortunate disconnect is the brain-reserve hypothesis, which suggests that people who have more cognitive ability and more neural tissue to start with - sharper minds, broadly - may be better able to withstand the ravages of age. "In some ways, you could think of it like a trained athlete who might be able to resist some atherosclerosis of the heart," explains Dr. Bradley Hyman, director of the Massachusetts Alzheimer's Disease Research Center and a professor of neurology at Harvard Medical School...
Because of their late start (researchers had intended to study mice from early ages but were stymied by technical difficulties), scientists weren't sure they could expect clear results. However, even administered late in life, rapamycin delayed the deaths of the longest-lived male mice by 101 days and by 151 days in the longest-lived females - the equivalent of about 13 years on average in humans - compared with mice with no treatment. In terms of life expectancy when treatment began (or average remaining lifespan when the mice were 600 days old), that translates to an increase...
...estimate 18 to 24 months to start seeing progress, but back in D.C., lawmakers want to see results in a year. How do you rectify this? It's going to take longer than 18 to 24 months to make permanent progress. What I want to see here in stages is, first, if in a fairly limited time we can focus our force on fighting the war that we want to fight, the right kind of counterinsurgency strategy; and second, if we can organize ourselves, in terms of command and control structures, in terms of unity of effort, in terms...
...effectiveness. Because we are competing with the Taliban for influence and control of the population. The analogy that a smart young guy I work with is that it is an argument. In conventional war, what you do is, you have an argument, and when the argument is over, you start fighting. And no one thinks during the fight, afterwards you will end up going to the peace table. And you end up with a completely different outcome than you wanted. Counterinsurgency is an ongoing argument. Everything you do in an operation or influence is trying to convince the population...
...review? I think it is going well. We didn't start from scratch. We are using previous assessments that were done last fall and winter. And so what we are doing is bringing in a lot of smart people and letting them do their business. It allows us to bring talent to focus. It gives me time to take a look and not make any decisions before their time. But I think it is going to validate some things we are doing and will shape our thinking. I don't think we are going to open the 60-day plan...