Word: steege
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Dates: during 1990-1999
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...Most patients die of metastases-related disease," said Patricia Steeg, a molecular biologist at the National Cancer Institute in Bethesda...
...phone has been ringing off the book," Steeg said. "Labs around the world are probably repeating the experiment...
...This is an extremely important avenue in cancer research," Steeg said. "Work of this caliber doesn't come around often...
...reason for the difference may lie in a gene known as nm23, first identified by Steeg in 1988. It seems to help mature cells stop dividing and arrange themselves in an orderly fashion. Steeg's research suggests that in cancer cells this crucial gene often malfunctions. When she introduced a normal nm23 gene (nm stands for nonmetastatic) into highly malignant human breast cells, then injected these cells into mice, their tendency to form metastases dropped as much...
...this reasoning, even metastatic cancer may eventually be brought to heel. Squeezed into a tiny cubicle day after day at the National Cancer Institute, Patricia Steeg stares at colonies of aggressive breast-cancer cells that have shut down the protective nm23 gene. Soon she will squirt over these colonies newly identified antitumor compounds. Among them she hopes to find one, maybe more, that interferes with metastatic growth. A total of 14 of these compounds are already sitting in a freezer in her lab -- white crystals that cluster like snowflakes in the bottom of test tubes. If these fail to have...