Word: steroided
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Like other steroid hormones (e.g., testosterone, androsterone, progesterone), cortisone is a tough chemical customer. Its molecules are built around the steroid nucleus" (TIME, Jan. 29) which has three six-atom carbon rings and one five-atom ring in the proper spatial arrangement. To build such a molecule from scratch was considered so difficult that few chemists ever hoped to accomplish...
...with Woodward's total laboratory synthesis of a steroid from coal tar, it is felt that the starting materials in the interconversions and consequently the desired steroids, will be more available...
Robert B. Woodward, professor of Chemistry, will read a paper before The Chemical Society of London tonight announcing that he and a research team of four men have completed the first total synthesis of a complete steroid...
Many ways have been worked out already for converting one steroid into another...
Syntex uses a vegetable raw material, cabeza de negro (niggerhead), a Mexican wild vine whose lumpy, woody root contains a soapy-feeling compound called sapogenin. In its raw state sapogenin is not a hormone, but its molecule contains the basic steroid nucleus.*This can be separated by a simple process and built up chemically into any number of hormonelike compounds...