Word: steroids
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Dates: during 1940-1949
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Dobriner points out that steroid identification is not a good test for early cancer. It is not sure; it takes too long, and it costs too much ($10,000 for a complete job). But he is cutting down the time and cost. As he collects more records, other startling facts are showing up. For instance, people with hypertension (high blood pressure) generally excrete a special steroid. No one knows why, but Dobriner hopes to find out. The mysterious steroids from the glandular orchestra are apparently concerned with all the changes in the body's cells. "If you want...
...unknown "anti-rheumatic substance X" might be a hormone from the adrenal glands. In 1946, with the help of Merck & Co. chemists, they developed a compound from the adrenal glands of cattle. It was called Compound E (full name: 17-hydroxy-11-de-hydrocorticosterone). Compound E belongs to the steroid group of body chemicals. So do the sex hormones (a link with relief during pregnancy) and some bile products of the liver (a link with jaundice). Compound E was obtained later from an element of bile. Seven months ago Mayo's began treating human patients...
...Hoagland & Pincus thought that fatigue might be reduced by feeding men a steroid substance to counteract their losses. They found that pregnenolone, a synthetic steroid, seemed to do the trick. They have not determined just how it works, but when 50 milligrams of pregnenolone were given per day, efficiency and stamina generally improved...