Word: sterol
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Dates: during 1930-1939
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...jaundice and kidney and lung infections. In every case bleeding stopped within five minutes, the normal coagulating time, even though the patients had been bleeding as long as two hours. In many cases bleeding ceased within 45 seconds of injection. Oxalic acid thus appeared likely to supplant snake venom, sterol (solid alcohol) and other makeshift coagulants, likely to save thousands of lives every year...
...three. Clotting time of normal male rats, normal dogs and bleeder dogs was reduced about 50%. Chicks which had been given a diet deficient in Vitamin K (bloodclotting vitamin found in leafy vegetables and cereals) showed a reduction in clotting time from about 17 minutes to five after sterol injections. Although the sterol acts like Vitamin K, said the scientists, it is an entirely different substance. Its effects lasted for several days...
From the livers of fresh-killed dogs, lambs and pigs they extracted a sterol (solid alcohol) which they dissolved in sesame oil. Then they artificially lengthened the clotting period of rats and dogs by tying up their bile ducts. Small amounts of the sterol were injected under the skins of the rats, into the veins of the dogs. Normal rats and dogs were also injected. Before and after injections the scientists measured the coagulation time of each animal by drawing a drop of blood from a vein onto a glass plate exposed...
Biochemists were no sooner positive of the hormone-vitamin relationship in the growing processes, than they discovered a sterol-like substance in coal tar which causes certain kinds of cancer. Cancer is a form of growth, but unregulated. The cancerogenic coal tar "sterol" causes the same sex changes in rats as does the hormone theelin. The breasts and uterus are common sites of cancer, and many an investigator has suspected a sex hormone as a possible cause. Knowledge of growth, hormones and vitamins are becoming interlaced to the biochemist's delight. He is confident that from them...