Word: streptomycinate
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Dates: during 1940-1949
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Five-year-old streptomycin, like others of the "wonder drugs," has its drawbacks (TIME, March 1). Among its worst effects (which may pass or may be permanent) are dizziness, deafness, and damage to the kidneys. But streptomycin has been the best drug doctors have found for treating tuberculosis. The problem has been to make it safer...
Three drug-manufacturing firms (Squibb, Merck, Parke-Davis), experimenting with variations on streptomycin, found a complex chemical answer: dihydrostreptomycin (two atoms of hydrogen added to the original antibiotic). Two teams of doctors immediately started testing it. Last week the first public announcement of results was made in St. Paul, Minn. The news was hopeful...
...Selman A. Waksman, 60, Russian-born Rutgers University biologist, discoverer of streptomycin, and Dr. Rene J. Dubos, 47, French-born Rockefeller Institute biologist, honored jointly for their pioneer work in antibiotics...
Anyone who has had to look into the eager, happy faces of anxious relatives and patients who have just read that streptomycin is practically a sure cure for tuberculosis, explain as gently as possible that the wonder drug has its limitations and is unsuitable for their particular sufferer, and watch hope change into sickening despair, can attest to the damage done by overenthusiastic writing on such topics...
...studies on muscular contraction, after going to Lederle concentrated on folic acid (part of the vitamin-B complex), helped develop its derivatives, teropterin and aminopterin (now being used to fight cancer), directed research that produced the new antibiotic, aureomycin (a cure for serious infections untouched by penicillin or streptomycin...