Word: streptomycinate
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McDermott of New York Hospital-Cornell Medical Center. Reporting on their findings at a Veterans Administration conference in Atlanta last week, Dr. Hinshaw explained that Tibione belongs to a group of chemicals (the thiosemicarbazones) which are new to medicine. It is unrelated to the antibiotic streptomycin - or to para-amino-salicylic acid (P.A.S.), the only other chemical previously known to be effective against tuberculosis...
There is need for such a combination because streptomycin, more than any other of the antibiotics, tends to develop resistant strains of germs. Some strains learn to live with it, even becoming dependent on it-as if a rat began to fatten on rat poison. The resistant strains can be highly dangerous; if they infect another victim, he cannot be cured by streptomycin or anything else yet known...
...already been used with success as a last desperate measure. Just before Labor Day, a fat but unhappy farmer was admitted to Pennsylvania Hospital in Philadelphia. He had a deep-seated infection caused by a common microbe, Aerobacter aerogenes, which is usually a pushover for penicillin or streptomycin...
...farmer's germs were a special strain. They had licked their weight in penicillin, and come back to knock out streptomycin, chloramphenicol and aureomycin. Unchecked, they were a sure bet to kill the farmer. Dr. Garfield G. Duncan pitted the tough germs in a test tube against neomycin. The drug murdered them...
While Waksman waits to set up his institute with streptomycin money, the search for better antibiotics goes on. The requirements for a new antibiotic seeking membership in the select club are getting stiffer all the time. Explains Waksman: to qualify, a new drug must kill some kinds of germs more effectively than any drug now known; it must work well in the body and not damage the body; it should be stable and soluble in water...