Word: streptothricin
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Dates: during 1944-1944
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...Streptothricin can kill a mouse, but many times the therapeutic dose is required...
Another drug made by a microscopic organism showed signs of becoming important last week. The Journal of the A.M.A. published an editorial on streptothricin, derived from Actinomyces lavendulae, a mold-like bacterium. Features of Streptothricin: 1) besides attacking many Gram-positive (blue-staining) bacteria, it attacks many of the Gram-negative (red-staining) against which penicillin is almost powerless-germs of typhoid, dysentery, etc.; 2) it is safe in therapeutic doses...
...Streptothricin protects mice against 10,000 times the ordinary lethal dose of Salmonella schottmülleri (paratyphoid fever organism), Escherichia coli (colon bacillus) and Bacterium shigae (cause of Shiga dysentery). The drug's usefulness against typhoid bacteria has not yet been tested in mice, but it is effective against test-tube typhoid...
...Streptothricin can be given by vein, injection under the skin, or by mouth...
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