Word: stress
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Dates: during 2000-2009
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...Finishing last, of course, wasn't just the province of tiny island nations or war-ravaged countries. Even athletic giants could crash. American diver Justin Wilcock was still recovering from a stress fracture in his back, but he insisted on competing, against his coaches' advice, reasoning that you don't dedicate 13 years of your life to a sport only to pull out. During one of his dives, the Utah native's foot scraped the board. Another awkward plunge resulted in a score of zero, and Wilcock ended the night at the bottom of the 3-m springboard preliminary competition...
...pretty obvious even to nonscientists that how you get there depends partly on the genes you are born with and partly on lifestyle--what and how much you eat, where you live and what types of stress and trauma you experience. How much depends on each factor, though, was unknown until Swedish scientists tackled the problem in 1998. They did it by looking at the only set of people who share genes but not lifestyle: identical twins who were separated at birth and reared apart. If genes were most important, you would expect the twins to die at about...
...seems to slow aging. Sinclair has found, for example, that resveratrol, a chemical found in red wine, increases life-spans of yeast and fruit flies. It works by amplifying the action of a molecule called SIRT1, which is present in all life forms and is produced in response to stress. "It's like a cell's 911 center," says Sinclair, and resveratrol is like a false alarm...
That fits with one of the leading theories about why CR works in the first place: starving the body puts it under mild, constant stress, priming it to resist the more severe stresses that make cells age--a sort of self-vaccination against decline. "With resveratrol," says Sinclair, "we're tricking the body into thinking it's not getting enough calories." If he can create a form of resveratrol that's easily absorbed by human cells and can demonstrate that it works without dangerous side effects, Sinclair may eventually come up with what amounts to an antiaging pill...
...widely used stress test, or treadmill test, may not be finely tuned enough to catch early heart disease, says a study in the Journal of the American College of Cardiology. Researchers found that 56% of the more than 1,000 patients who passed a treadmill test, which measures how well the heart withstands exercise, scored above 100 on a follow-up screen for coronary calcium deposits. That puts them at elevated risk for a heart attack within five years. The study's authors say at-risk patients--such as smokers, diabetics or those with high cholesterol or blood pressure--should...