Word: strongly
(lookup in dictionary)
(lookup stats)
Dates: during 2000-2009
Sort By: most recent first
(reverse)
...Alzheimer's is, of course, the central question driving legions of researchers. Are some people's brains capable of building detours around damaged neural circuits? Is there a gene that may help certain people rebuild and repair damaged brain tissue better than others can? Iacono suggests that's a strong possibility, pointing to the presence of one particular gene, APOE2, in 30% of patients with asymptomatic Alzheimer's. The next step in his research, he says, is to understand how this gene works...
Although the results are untested in humans, they do suggest that aging could be slowed by drugs. Exactly how rapamycin works is "still an open question," says Randy Strong, a pharmacology professor at the University of Texas Health Science Center at San Antonio and one of three lead authors of the study. But he and his colleagues were prompted to test the aging effects of rapamycin, which was discovered in Easter Island soil samples about 40 years ago, after noting that the compound appeared to affect cell growth in lab animals in much the same way as calorie-restricted diets...
Scientists think rapamycin's cellular target - called mTOR for "mammalian target of rapamycin" - helps regulate the body's response to nutrients and may also, according to Strong, "gear up responses to stress," such as the oxidative stress that damages proteins and DNA and contributes to disease development. "What we're doing with rapamycin," Strong says, "is we're actually tricking the cells into thinking that they're depleted of nutrients. Rather than the animals losing weight - we haven't noticed any weight loss - they may be just using their proteins more efficiently, and then repairing proteins more efficiently...
Rapamycin's life-extending effect has been demonstrated by other researchers in past studies of worms, fruit flies and yeast; the drug appears to interfere with a similar cellular process in those species too. "I think this is a big leap from those invertebrate species to mammals," says Strong, who is also a senior research scientist for the Department of Veteran Affairs. "This gives us a good idea that perhaps it would work in humans...
...immunosuppressant, it can make users susceptible to opportunistic infections. It has also been linked to hyperlipidemia, or high levels of triglycerides in the blood, which can lead to heart disease. It's unclear whether these problems would counteract any longevity benefit that rapamycin might provide in humans. Says Strong, "I think more immediately, people are starting to look at [rapamycin] for age-related diseases like Alzheimer's disease, Parkinson's disease or kidney disease." The drug has also recently entered clinical trials as a human cancer treatment, while another study published last year showed that it may reverse mental retardation...