Word: successful
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Dates: during 1990-1999
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...Maryland-based Human Genome Sciences have discovered two new angiogenesis inhibitors -- proteins that can starve a tumor by choking off its blood supply -- called METH-1 and METH-2 that may be 50 times more effective than anything currently being studied. TIME science writer Christine Gorman says that while success in the lab is all well and good, she warns that advances like these have a long history of turning into dead ends. "Angiogenesis inhibitors have a 20-year history of disappointment when they?re tried outside the laboratory," she says. "The problem is, blood supply is how we live...
...More promise may lie in a sort of mimicry, studying the body?s own approach to fighting cells that go bad ? and Thursday saw some success on that front too. Publishing in Science magazine, a team from the M.D. Anderson Cancer Center in Houston have identified a protein, called Fas ligand, that they think is the body?s own treatment for skin cancer from within. You may know it as peeling. "The body?s traditional respose to mutation is ?You change, you die,?" says Gorman. "When a skin cell sustains enough sun damage to its DNA that it may turn...
George W. Bush was falling into a rut. For all his early success--a gaudy lead in the polls, a $37 million-and-rising war chest--the Texas Governor, after a month of delivering the same airy, slogan-rich speech, was sounding stale and tired by mid-July. His Republican opponents were calling him the all-money-and-no-message candidate, and the label was beginning to stick. (Sensitive to the charge, Bush half seriously asked his finance chairman if there was any way "to slow down" the flow of contributions.) And to make matters worse, Bill Clinton was trying...
...also done very well, placing among Amazon.com's top books. Older, more established writers have had luck too. Annie Proulx's newest collection of strikingly uncommercial short stories, Close Range, has sold nearly 100,000 copies. Scribner, the book's publisher, would have considered half that number a success. And at Knopf, senior editor Anne Close says short-story collections such as Lorrie Moore's Birds of America have fared very well this year...
...brand. His legacy will be one of brilliance, complexity, flair, passion and proof that enduring values can indeed travel around the world. The strength of David's guiding principles, his respect for the consumer's intelligence and his determination to have truth be central to the commercial success of his agency, Ogilvy & Mather, made it possible for following generations of advertising agencies to prosper. By carefully disseminating his beliefs, David changed the face of advertising. His writings and books continue to provide not only the "how-to's" of contemporary best practices but also the inspiration for gloriously big, business...