Word: sulfa
(lookup in dictionary)
(lookup stats)
Dates: during 1940-1949
Sort By: most recent first
(reverse)
Though far from being a drug on the market, the number of sulfa drugs has increased so rapidly during the past two years that not even doctors can keep their uses straight. In the July issue of California and Western Medicine last week, Drs. Lowell Addison Rantz and Windsor Cooper Cutting gave a brief review of the whole sulfonamide family, with the diseases on which each drug works best. The ideal sulfa drug, they said, is still to seek. Requirements: it must be as strong as possible, without poisoning the patient...
...present." It is a powerful weapon against pneumonia, staphylococcic infections and a great range of streptococcic infections. Resultant anemia and cyanosis are "less marked" than with the use of sulfanilamide. But sulfathiazole has other drawbacks: 1) it causes fever, skin rash, inflammation of the eyes more severely than other sulfa drugs; 2) it must be used for a relatively longer period of time, thus increasing danger of complications...
Magic Five. During the last three years in Manhattan, Pharmacologist Marvin Russell Thompson and Biochemist Gustav Julius Martin of the Warner Institute for Therapeutic Research have painstakingly poisoned 30,000 rats, mice and rabbits in their research work. When they gave the animals huge doses of sulfa drugs, or of common poisons, the scientists found that five basic substances present in normal blood promptly dwindled or disappeared. The vital chemicals: 1) ascorbic acid (vitamin C); 2) choline, a nitrogen compound, a constituent of nerve tissue; 3) cystine, a sulfur-containing compound found in hair and finger nails; 4) glycine...
...example, arsenic, which killed 65% of the rats, killed only 15% when it was given with the detoxicants; a dose of sulfathiazole that would ordinarily have killed 40% of a large group of mice killed none. At the same time, the mixture seemed to strengthen the curative powers of sulfa drugs...
Yellow Marrow. Often large doses of sulfa drugs drain the body's reserves of white blood cells. (So does arsphenamine, the syphilis specific, and certain sedatives and painkillers.) A deficiency of white blood cells may also be caused by disease of the bone marrow, where most of them are produced. This form of blood disease, known as agranulocytosis or leukopenia, leaves the body at the mercy of any bacteria which may enter the bloodstream. For the white cells, which move about like amebae, are the body's shock troops; they gobble up invading bacteria, produce antidotes which neutralize...