Word: sulfa
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Dates: during 1960-1969
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...Central Highlands, the Viet Cong have found an ally in an especially severe form of malaria resistant to the most potent drugs. Now an Army doctor, Major Peter J. Bartelloni, reports in the A.M.A. Journal that the wonder druggists have done it again. A new, long-acting sulfa, sulformethoxine, developed in Britain, has sent the cure rate soaring and, just as dramatically, reduced the relapse rate...
...Bartelloni's team added sulforme-thoxine in an "SPQ" combination. Then they dropped the quinine and dosed malarial G.I.s with a combination of the new sulfa and pyrimethamine. Result: The new drug not only cures patients faster and kills parasites in the blood, but reduces the relapse percentage from 40% to a scant...
Doctors have long been warned to go easy on antibiotics and sulfa drugs. When used with routine frequency, such germ killers may defeat their own purpose by leading to ever more resistant germs. Now comes worse news: the appearance of drug-resistant bacteria that can foil several antibiotics at once. The disturbing explanation is that certain germs "catch" this power of resistance simply by contact with one another. As a result, some infections of the intestinal and genitourinary tracts are becoming tougher than ever to treat...
From the first sulfa compounds of the 1930s to the latest molecular manipulation of penicillin, the wonder drugs of modern medicine have carried a high price tag. And the bill keeps getting bigger. Patients are paying it with an increased number of drug-induced diseases...
...drug wanted to label it "effective in a few" cases of cancer. Goddard said that of 127 patients treated in trials, only five had had temporary reductions in the size of tumors; to him this was not at all effective. In another instance, the maker of a long-acting sulfa, which had been clinically proved to be effective only in treating the genitourinary tract, wanted to imply on the label that the drug could be prescribed to treat acne...