Word: sulfa
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...Doctors have recently discovered that babies with blood disorders caused by Rh-factor differences in their parents have a greater chance of being born alive if their mothers during pregnancy are treated with: 1. Mescal beans. 4. Sulfa drugs...
...when sulfa drugs were the wonders of the medical world was quickly followed by the antibiotic age, and then came a time when hormones held the center of the medical stage. Next, thought some enthusiastic researchers, would come the age of enzymes-some of nature's complex chemicals which act as catalysts in countless physiological reactions. A star among the enzymes was expected to be trypsin, secreted by the pancreas. It was known to dissolve dead tissue around wounds, but a team of Manhattan researchers led by Dr. Irving Innerfield made far more dramatic claims...
...Children's Memorial Hospital in Chicago, Drs. Howard S. Traisman and L. Martin Hardy reported to the Illinois State Medical Society, 55 of the children got only the old-fashioned treatment; 37 got a sulfa drug in addition, and similar groups received one of two antibiotics. Children in the standard-treatment group got well faster than the others; when they had complications (such as ear infections and pneumonia), these showed up sooner and were cleared up earlier with the proper drugs...
...less elusive than the cause of toxoplasmosis is its cure. Antibiotics are almost useless. Sulfa drugs are being tried, and if they do any good, the improvement should be most obvious in acute cases. But because toxoplasmosis is hard to identify, the patient often does not get the treatment soon enough. Last week Microbiologist Don E. Eyles of the National Institutes of Health reported a hopeful new lead: Daraprim, which has already shown promise against the protozoa of malaria (TIME, Sept. 1), is effective against toxoplasmosis in mice when given with sulfadiazine. Now the trick is to extend the benefits...
...Sulfas. By the time the vitamin frontier was thickly settled, another frontier was being opened. In 1935 the French broke the secret of a new German drug and published it: a simple substance derived from coal tar would kill the streptococcus germs that often caused fatal infections. The drug was Prontosil; from it came sulfanilamide, first of the modern "wonder drugs" and first of a long line of sulfas. Other companies were the first to find high-powered, patentable variants like sulfamerazine, sulfadiazine, sulfathiazole and sulfaguanidine. Merck chemists got what looked like a dud: sul-faquinoxaline. Never proved safe...