Word: sulfamethylthiazole
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Chemists Russell J. Fosbinder and Lewis Aldro Walter of Maltbie Chemical Co. at Newark, N. J. last year created a new sulfanilamide product: sulfamethylthiazol. Biologists of Winthrop Chemical Co.'s Albany Laboratories fed the drug to mice infected with Staphylococcus germs, found it far more powerful, far less toxic than sulfapyridine. But even after hundreds of trials, no one dared experiment on human beings...
Last September, a friend of Dr. Carroll's lay in a St. Louis hospital dying from an infected, pus-dripping kidney. As a last desperate measure, Dr. Carroll wired for a supply of sulfamethylthiazol. He gave his friend a small amount of the bland white crystals, both in capsules and injections. When the patient showed signs of improvement, Dr. Carroll continued feeding him from six to 14 grams of the drug every four hours for 16 days. In a few weeks the patient, said cautious Dr. Carroll, had "apparently recovered...
...with remarkable success on four other staphylococcic patients, including a baby. "No toxic symptoms or signs ascribable to this drug were seen," reported Dr. Carroll, "except for a slight nausea." About the future of the drug, which is not yet on the market, he hazarded no comment. Last week sulfamethylthiazol was tried on two Staphylococcus victims in a Midwest hospital, and on one in Manhattan, with hopeful results. But still restrained is the cautious enthusiasm of physicians, who cannot commit themselves on the drug until it has been tried on many more patients...
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