Word: sulfas
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Dates: during 1950-1959
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...less elusive than the cause of toxoplasmosis is its cure. Antibiotics are almost useless. Sulfa drugs are being tried, and if they do any good, the improvement should be most obvious in acute cases. But because toxoplasmosis is hard to identify, the patient often does not get the treatment soon enough. Last week Microbiologist Don E. Eyles of the National Institutes of Health reported a hopeful new lead: Daraprim, which has already shown promise against the protozoa of malaria (TIME, Sept. 1), is effective against toxoplasmosis in mice when given with sulfadiazine. Now the trick is to extend the benefits...
...Sulfas. By the time the vitamin frontier was thickly settled, another frontier was being opened. In 1935 the French broke the secret of a new German drug and published it: a simple substance derived from coal tar would kill the streptococcus germs that often caused fatal infections. The drug was Prontosil; from it came sulfanilamide, first of the modern "wonder drugs" and first of a long line of sulfas. Other companies were the first to find high-powered, patentable variants like sulfamerazine, sulfadiazine, sulfathiazole and sulfaguanidine. Merck chemists got what looked like a dud: sul-faquinoxaline. Never proved safe...
...Cabell Brown, Government-appointed president and former corporation lawyer, chemical and drug sales steadily climbed from $2.8 million in 1942 to last year's $15.4 million. Earnings per share rose from 43? to $3.12. Schering was the second company to put cortisone on the market, has marketed new sulfa and penicillin products, holds a prominent place in the antihistamine field, has introduced several important new drugs, including "Dormison" (for insomnia), and "Prantal" (for peptic ulcers...
...Conclude ... In Tulsa, Okla., Mrs. Emma Conway complained to police that her husband, after a spat, had: 1) mixed alcohol with her cosmetics, 2) smeared sulfa cream on her clothing, 3) cut the straps off her shoes, 4) dumped a hot roast with gravy all over the kitchen, 5) broken the bedroom mirror and two flower vases, 6) slashed her brassieres to shreds...
During his graduate studies at Chicago in 1937, Dr. Starke got early training in the use of sulfa drugs against pneumonia. Back in Sanford, he soon saw a serious case of double pneumonia and venturously tried sulfa. White doctors, including the one who was officially in charge of Starke's patient in the hospital, sneaked the charts out for a private look at the progress of a treatment which they had not yet dared to try. Says Dr. Starke: "If the sulfa hadn't worked, the ax would have fallen...