Word: sulfas
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From the first sulfa compounds of the 1930s to the latest molecular manipulation of penicillin, the wonder drugs of modern medicine have carried a high price tag. And the bill keeps getting bigger. Patients are paying it with an increased number of drug-induced diseases...
...drug wanted to label it "effective in a few" cases of cancer. Goddard said that of 127 patients treated in trials, only five had had temporary reductions in the size of tumors; to him this was not at all effective. In another instance, the maker of a long-acting sulfa, which had been clinically proved to be effective only in treating the genitourinary tract, wanted to imply on the label that the drug could be prescribed to treat acne...
Herculean Check. Acting on the advice of such specialists and on his own preferences, Goddard brusquely reversed Sadusk in a drumfire series of decisions which drastically restricted the use of long-acting sulfa drugs, attacked the inflated advertising for Peritrate (a painkiller for angina pectoris), and flatly forbade the further manufacture of over-the-counter throat lozenges containing antibiotics. He also promised a congressional committee that FDA would promptly tackle the herculean task of checking the efficacy of 3,000 drugs marketed between...
...physicians should be free to make their own choices from among many available drugs, all of which have some degree of danger. His opponents now accuse him of betraying the public interest in favor of protecting the pharmaceutical manufacturers. Some recent examples of action, inaction and disputed decisions: ≫ SULFAS. FDA last week announced that it was requiring new labeling on two long-acting sulfa drugs marketed by three firms,* "to warn against rare cases of a severe and sometimes fatal side effect," a blistering and ulceration known as the Stevens-Johnson syndrome. There have been 81 reported U.S. cases...
Died. Dr. Perrin Hamilton Long, 66, professor of preventive medicine at Johns Hopkins Medical School from 1940 to 1951 and the man credited with a major role in popularizing the use of sulfa drugs in the U.S., who in 1936 heard reports of the anti-infection properties of a sulfa-derivative German dye, carried out his own experiments on sulfanilamide, thus raising the curtain on the age of wonder drugs; of a heart attack; in Edgartown, Mass...