Word: suramin
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...stop or slow the reproduction of the AIDS virus at least temporarily. But they produce debilitating side effects, like kidney damage, which make them unsuitable for prolonged treatment. Among these drugs are HPA-23, a compound developed at the Pasteur Institute in Paris, where Rock Hudson sought treatment; Suramin, originally used to treat such parasitic disorders as African sleeping sickness; and Foscarnet, a drug being tested in Sweden and Canada...
...researchers at a handful of medical centers around the country are testing another antiviral preparation, called Suramin, which was originally used to combat African sleeping sickness. Like HPA-23, the drug appears to stop the proliferation of the AIDS virus, but it does not necessarily improve the patient's condition. Other antiviral substances, including Ribavirin and Foscarnet, now being studied in Sweden and Canada, are in even earlier stages of investigation...
While reports of promising anti-AIDS drugs surface frequently, several scientists noted, test results have so far been disappointing. Suramin, highly touted last year, has proved ineffective, if not actually harmful. Eager for any hopeful note, some reporters at the conference seized upon and overplayed a report by Dr. Anthony Fauci of the National Institutes of Health. Fauci revealed that one of his AIDS patients had regained his health and returned to work after treatment that included a bone-marrow transplant from his identical twin. Whether the patient has been permanently cured remains in doubt, and two other victims...
...having any effect, it may be something a patient will have to use the rest of his life," Marlink says. Still, alpha interferon and AZT, are the two most promising drugs around at present, better than those researchers--including Groopman--have tested before such as the much-touted suramin, Marlink says...
...announcement and the resulting furor underscore the frenetic pace of AIDS research. At the NIH in Bethesda, Md., calls come in virtually every day from drug manufacturers claiming to have a new treatment for the disease. About half a dozen drugs are currently under serious study. Several, including ribavirin, suramin and one called compound S, have shown promise in blocking the replication of the AIDS virus. But few, if any, have demonstrated the potential to rebuild the devastated immune systems of AIDS patients...
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