Word: sv40
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
Associate Professor of Pediatrics Dr. Robert L. Garcea '70 reported last week in the Journal that he and colleagues at the Institute have correlated DNA sequences in pediatric brain tumors and in simian virus 40 (SV40...
...SV40 is known to lead to tumors in certain animals, including humans. The rare tumors associated with the virus usually appear before two years of age in humans, and doctors often have difficulty treating them because they lie deep within the brain, in an area known as the choriod plexus, which manufactures cerebro-spinal fluid...
Garcea said in an interview yesterday that past research has implicated a protein, called a t-antigen, in all choriod plexus tumors in laboratory animals. The t-antigen has been shown to result from the expression of an SV40 DNA sequence...
...pediatrician said that early use of transgenic mice, into whose gametes the sequence coding for the t-antigen was inserted, led to the conclusion that SV40 was involved when all of the animals developed the tumors...
Eventually, using DNA probing techniques on 31 pediatric tumor samples, Garcea showed that a large fraction of the samples reacted with the sequence for the SV40 t-antigen...