Word: sv40
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...prize, were the steps that immediately preceded it. The virus he wanted to introduce into the bacterium was itself a hybrid. By ingenious use of enzymes that can cut, patch and join nucleic acids, he and his colleagues managed to splice DNA from a bacterial virus into SV40's genes, forming a single closed loop. That was the first time scientists had been able to link the genes of two distinctly different species, and thus created the prospect of producing entirely new life forms...
Using the enzyme discovered by his colleague, Nathans, 49, applied it to his work with a monkey virus, SV40, known to cause cancer in animals...
...Nathans showed that the enzyme broke SV40 DNA into eleven well-defined fragments. Two years later he described the way SV40 was split when two other en zymes were used. By analyzing the frag ments produced by all three enzymes, Nathans was able to map the SV40 genes...