Word: synovium
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...routine, as was his follow up. The knee got better. I asked every oncologist I knew if they ever heard of this as a side-effect of chemotherapy. Some of the chemo they were giving Charlie was cherry-red - the thought was that somehow the tissue lining the knee (synovium, that normally makes the tan joint fluid) had been taking the red chemo molecules and changing them into something fluorescent green. This was just a guess though - the red stuff doesn't go green in any known situations...
...their symptoms can be similar, the two diseases are very different. Unlike osteoarthritis, which is focused on a particular joint, rheumatoid arthritis is a systemic disease--an autoimmune disorder in which the body's defense system attacks the joints by way of the thin layer of cells called the synovium that line and lubricate the joints. The runaway immune response clogs the synovium with infection-fighting cells that release proteins called cytokines. These are compounds that fuel inflammation. The synovium becomes engorged with new blood vessels and begins to grow, kudzu-like, penetrating and further damaging cartilage and bone...
...etanercept (Enbrel), infliximab (Remicade) and anakinra (Kineret). These are genetically engineered versions of naturally occurring molecules that bind or block the activity of cytokines. Also in very early development are drugs designed to reduce the formation of the blood vessels that feed the tumor-like growth of the synovium...
...Among the causes of pain in rheumatoid arthritis are inflammation of the synovium (the membrane lining the joint capsule) and subsequent erosion of the enclosed cartilage and bone. Doctors generally prescribe painkillers and other anti-inflammatory drugs including common aspirin. But according to Dr. Alan Wilde of the Cleveland Clinic, early surgery may provide more permanent relief and slow the progress of the disease as well. Wilde told a scientific session of the Arthritis foundation that he had performed synovectomies on 39 patients, delicately removing the inflamed tissue from a total of 121 finger joints. Most of the patients experienced...
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