Word: tagamet
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Dates: during 1990-1999
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...race to corner the heartburn market, Merck's Pepcid and SmithKline Beecham's Tagamet have the early lead. Both drugs boasted stellar records as anti-ulcer drugs in the prescription market and gained final U.S. approval for over-the-counter sales in April and June, respectively. Despite Zantac's late start, its popularity may enable it to overtake its rivals. Currently, it is the world's best-selling prescription drug. Analysts expect the three manufacturers together to spend some $300 million to tout their products...
...consumer's health and well-being are not, of course, the only factors at stake in these decisions. SmithKline lost its patent protection for Tagamet last year; Merck's exclusive rights to Pepcid end in 2000; and Glaxo's claim to Zantac expires in 2002. By law, any company that switches to an over-the-counter preparation of its product enjoys a three-year monopoly before other firms are allowed to manufacture a generic version. All three companies are planning to use the time to establish name recognition and brand loyalty among consumers...
...followed by a catheter ($30), urinalysis ($22), a steroid injection and lab work to check organ function ($71); anesthesia ($345); an IV attached to a leg ($110); a biopsy ($45); upper and lower gastrointestinal endoscopy for fiber-optic images of his stomach, small intestine and colon ($75); antibiotics and Tagamet for the ulcer ($25); plus five days of hospitalization...
...nefarious H. pylori has also been linked to ulcers and gastritis -- inflammation of the stomach lining. Parsonnet and others believe that people with chronic duodenal ulcers should consider a course of antibiotics to knock out the bug rather than rely on costly medications like Tagamet and Zantac, which treat the symptoms, not the cause. Meanwhile, studies are under way in Colombia and Mexico to determine if a similar strategy of antibiotics could play a role in cutting the world's incidence of stomach cancer...
...bitter, went this month before the Senate environment and public-works subcommittee on toxic substances. Dallas petroleum consultant Tom Latimer, 36, testified that he used the widely sold insecticide diazinon six years ago to control grubs eating grass roots at the same time that he was taking the drug Tagamet to control warts. Neither chemical came with a warning of dangerous interaction, but the impact of diazinon, an organophosphate that inhibits nerve action, was apparently magnified by the Tagamet. Today his eyesight remains severely damaged; he has constant headaches; his memory, concentration and mental acuity are dulled...