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...probe cellular gene activity en masse, scientists first isolate the molecules that translate genes into proteins. They then copy these molecules into their corresponding DNA sequences, tag those sequences with fluorescent markers and pour the tagged sequences over the microarray. Active genes in this biochemical stew stick like Velcro to their single-stranded partners on the chip, creating patterns of fluorescent dots that reveal which genes are turned on. "This technology has fundamentally altered how we explore biology," says Dr. Olli Kallioniemi of the NIH, who studies gene expression in cancers...

Author: /time Magazine | Title: The Workhorse of Genomic Medicine | 1/15/2001 | See Source »

...more time means more money - and more people. And as the teaching shortage mounts, neither will be particularly easy to come by. The California plan boasts a $1.45 billion price tag, though officials there estimate the extra days could translate into a 50% increase in test scores. But while more appears to be better, more of the same-old lessons and techniques may not. So before Saturday cartoons morph into a sixth school day, educators ought to take an elongated look at what transpires during the other five. The bi-coastal calls for change are certainly an auspicious start...

Author: /time Magazine | Title: Mo' Time, Mo' Better Schools | 1/13/2001 | See Source »

...time when the tag 'singer-songwriter' was about as common as 'lady surgeon,' [the artist's] warm, croaking delivery often vaulted him up the charts...

Author: /time Magazine | Title: The 2000 TIME Current Events Quiz | 12/25/2000 | See Source »

...wears his omnipresent black running shoes, one crossed over the other. He's not in a quiet conference room at one of the local law offices placed at his disposal but in a Tallahassee, Fla., hotel lobby. As he writes, Boies turns to today's edition of the tag-along journalist who always seems to be hovering nearby and asks, "How do you spell 'auspices...

Author: /time Magazine | Title: Get Me Boies! | 12/25/2000 | See Source »

...became a symbol of Venter's disdain for authority, the new technique he developed for finding genes with it demonstrated his brilliance. By focusing on those bits of DNA that were actually doing something--as opposed to the long strings that had no obvious function--he was able to tag the relevant parts and decode them. These "expressed-sequence tags" enabled Venter to start identifying genes at a hitherto unimaginable pace...

Author: /time Magazine | Title: Gene Mapper | 12/25/2000 | See Source »

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