Word: tamiflu
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Dates: during 2000-2009
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...JAMA study, the CDC scientists report that infection with drug-resistant flu does not cause more severe illness or lead to more hospitalizations than infection with nonresistant strains. The study also finds that the resistant strain did not arise from overuse of Tamiflu; in fact, during the past flu season, the resistant strain was found widely in countries with low Tamiflu use, like Norway, but less commonly in places, like Japan, where Tamiflu use is high. If overuse had played a role in the emergence of the resistant strain, health officials might have recommended that clinicians restrict prescriptions...
...Researchers at the Centers for Disease Control and Prevention (CDC) first reported in December that 2% of influenza strains circulating in the 2007-08 season were resistant to the most popular antiflu remedy, oseltamivir, or Tamiflu. They warned that the prevalence of these strains would probably continue to increase, and indeed, early data from the current season suggest they have. Influenza is composed of three subtypes of virus, and last year 12% of one of those subtypes, known as H1, were resistant to oseltamivir. This year almost all of the H1 contingent, 98%, are resistant. (Read "Getting Closer...
...resistant strain is also treatable with antiviral medications other than Tamiflu; zanamivir, or Relenza, still combats all three subtypes of influenza. And for those for whom zanamivir is inappropriate - the drug comes as an inhaled powder and is not recommended for children under age 7 - the combination of Tamiflu and an older antiviral, Flumadine (rimantadine), can be effective in fighting the disease. (In 2006 the CDC recommended against prescribing Flumadine because another of influenza's three subtypes was resistant to the drug. But in combination with Tamiflu, the medication can be effective.) (Read "A Brief History Of: The Flu Vaccine...
...Tamiflu doesn't work, then what else can I take...
Another antimicrobial, zanamivir, or Relenza, is still effective against the circulating Tamiflu-resistant strain. However, that drug, which is an inhaled powder, is not recommended for children under 7, for whom a combination of Tamiflu and an older drug, rimantadine, can be used to control the infection. Since every flu infection is made up of three different types of influenza virus, both Relenza and rimantadine still work to disarm the two types that are not resistant to Tamiflu...