Word: tamoxifen
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...years ago there wasn't a pill in the world that had been proved to reduce a woman's risk of developing breast cancer. Today there are two: tamoxifen, which doctors have used for more than 25 years to treat breast tumors after they have formed; and raloxifene, a newer drug that was originally designed to prevent osteoporosis but that, according to a study in last week's issue of the Journal of the American Medical Association, may also afford some protection against breast cancer...
Thus far only tamoxifen has been formally approved by the U.S. Food and Drug Administration for reducing the risk of breast cancer. But ever since preliminary data suggested that raloxifene might also help keep breast cancer at bay, the spotlight has been shifting toward the newer drug. Why? Because raloxifene, unlike tamoxifen, doesn't appear to increase a woman's risk of developing uterine cancer...
...balance even further in raloxifene's favor. Researchers, led by Dr. Steven Cummings of the University of California at San Francisco, reported that taking the drug for 3 1/2 years reduced a woman's risk of developing breast cancer an average of 75%. By contrast, a study of tamoxifen completed last year showed that it reduced the incidence of breast cancer 45% over four years. As an added bonus, raloxifene also lowered the amount of LDL, or "bad cholesterol," in the blood...
...into the body?s estrogen receptors in such a way as to both increase bone density and block breast cancer. There are apparent side effects to raloxifene, however, such as an increased risk of blood clots. And there are also side effects to the other well-known estrogenlike drug, tamoxifen, which can increase the risk of uterine cancer. "A new study is now under way to compare the benefits and risks of the two drugs," says Gorman. The perfect designer estrogen has yet to be found, she notes, but researchers? immense interest in the subject should provide women with...
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