Word: tamoxifen
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...Tamoxifen, used to treat breast cancer, made headlines in April when a study suggested it could also prevent the disease. But this week, two European studies showed no proof of prevention, casting doubt on earlier hopes. The studies differed in duration (the U.S. study was shorter) and in participants (one European study included low-risk women...
CANCER CARE Tamoxifen, the anti-breast cancer drug, is prescribed to too few patients. A study finds that it benefits women of all ages with the cancer, not just postmenopausal ones...
...time certainly seemed ripe for a breakthrough in cancer. Only last month scientists at the National Cancer Institute announced that they were halting a clinical trial of a drug called tamoxifen--and offering it to patients getting the placebo--because it had proved so effective at preventing breast cancer (although it also seemed to increase the risk of uterine cancer). Then preliminary reports indicated that another drug, raloxifene, might prevent breast cancer without triggering new malignancies. Two weeks later came the Times's report that two new drugs can shrink tumors of every variety without any side effects whatsoever...
...once did, trying to persuade researchers that his approach to cancer treatment has merit. Scientists are currently investigating 300 different substances for their potential to block angiogenesis. Twenty of those compounds have already entered clinical trials in humans. Indeed, researchers suspect that some of the latest cancer treatments, like tamoxifen, may themselves work in part by blocking the growth of newly formed blood vessels...
ANOTHER BOON FOR THE BREAST Just weeks after tamoxifen was shown to prevent breast cancer, early reports raise hope that another drug, raloxifene, may do the same--without increasing the risk of uterine cancer...