Word: tamoxifen
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...expensive) tests for different disorders. Women who carry a gene variant known to increase breast cancer risk, for example, would be able to begin mammograms earlier in life. Second, it would allow physicians to personalize medical treatments. In a few cases, this is already possible. The breast cancer drug Tamoxifen is much more effective in individuals who produce a certain protein that digests drugs in a certain way. Treatments based on the DNA you carry, known as “personalized medicine,” offer a range of benefits over current treatments: more precise doses of potentially toxic drugs...
...Since 60% to 70% of breast cancers grow in response to estrogen, half a dozen drugs, beginning with tamoxifen, introduced in the late '70s, work by blocking that hormone. Such drugs prevent cancer recurrences for 10 years or more in 50% of women with estrogen-sensitive tumors. Even for those with metastatic disease, hormone therapy can lengthen life and frequently will be more effective than chemotherapy. (Edwards told TIME, however, that her cancer was only slightly sensitive to estrogen, though she's waiting for new biopsy results to reveal "what receptors and markers I have...
...either Taxol or Taxotere. This potent regimen knocks out tumor cells and causes the familiar side effects of nausea and hair loss. If her original tumor was estrogen-sensitive - meaning growing in response to the hormone - then she is almost certainly taking an estrogen-blocking drug such as Tamoxifen. (See TIME's photo-essay "The Diary of Healing...
...TAMOXIFEN VS. RALOXIFENE...
...average, a month's supply of raloxifene costs $75 in the U.S., compared with $100 for tamoxifen...