Word: tamoxifen
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...effectiveness. “In tumors that depend on hormonal mechanisms to drive them, therapy that targets the hormones has a huge effect. As a result, there is not a lot of room for the added effect of chemo,” Garber said. Because hormone therapy drugs like tamoxifen reduce an ER-positive patient’s death rate by 30 percent, women with ER-positive tumors receive less benefit from chemotherapy than women with ER-negative tumors that do not respond to hormone therapy. The study results present doctors with a new challenge—deciding which patients...
...about 50%. Because Herceptin works by blocking a protein called HER2 that signals cells to divide and grow too fast, it is valuable only for the 20% to 30% of patients whose tumors are HER2-positive. Still, the news was greeted by many specialists as the biggest breakthrough since tamoxifen...
Known complications of tamoxifen are: hot flashes, increased risk for cataracts, uterine cancer, blood clots, sexual function and vaginal dryness...
...Tamoxifen has been used to treat cases of advanced breast cancer for over two decades, but has only been used as a preventative measure in the last 10 years...
...Tamoxifen is a selective estrogen receptor modifier, a type of drug that prevents estrogen—a key player in breast cancer— from binding to cells in breast tissue...