Word: tandearil
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Dates: during 1960-1969
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...Houck noted that three drugs, hydrocortisone, oxyphenbutazone (Tandearil) and indomethacin (Indocin), when injected into animals, all cause the release of an enzyme which is itself inflammatory-though all are prescribed as anti-inflammatory medicines in arthritis. This, he declared, is puzzling to the point of being "intellectually unpleasant." Dr. Arthur Bogden of Worcester, Mass., made the paradox still sharper. If hydrocortisone and aspirin are given to laboratory rats under certain conditions before they have arthritis, both have anti-inflammatory action. But after the rats have their arthritis, the hydrocortisone raises a certain enzyme level used as a measure of drug...
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