Word: targeted
(lookup in dictionary)
(lookup stats)
Dates: during 2000-2009
Sort By: most recent first
(reverse)
Scientists think rapamycin's cellular target - called mTOR for "mammalian target of rapamycin" - helps regulate the body's response to nutrients and may also, according to Strong, "gear up responses to stress," such as the oxidative stress that damages proteins and DNA and contributes to disease development. "What we're doing with rapamycin," Strong says, "is we're actually tricking the cells into thinking that they're depleted of nutrients. Rather than the animals losing weight - we haven't noticed any weight loss - they may be just using their proteins more efficiently, and then repairing proteins more efficiently...
...agents for extending life, other drugs may be further along in the pipeline - resveratrol, for one, which has also prolonged life in lab mice. But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species." It may guide researchers to target different proteins in the same pathway. "If those proteins react the same way to extend lifespan, then we might be able to get rid of unwanted side effects," says Strong...
...part of it ... if we went back to the concept of shock and awe, those are designed to shock command and control systems. And nations. You can shock and awe human beings, but it doesn't last. I've seen operations where kinetic strikes would go in on a target, and the enemy would come out shooting. They weren't awed...
Those numbers could be used by governments to establish a pathway for future emissions reductions. Suppose, for example, we wanted to hit a global emissions target of 30 billion metric tons of CO2 in 2030, or about a 30% cut from the business-as-usual forecast of 42 billion metric tons. That would translate to a global individual emissions cap of 10.8 metric tons of CO2, which 1.13 billion people - less than 15% of the global population in 2030 - would exceed. Emissions-reduction efforts would focus on the well-off people above the cap, whatever country they live in. That...
...financial innovation has turned out to be awfully hard, so in recent years believers in an automated Fed have turned to an equation concocted by Stanford economist John Taylor that takes in inflation, current economic growth and long-term-trend growth and churns out a suggested Fed interest-rate target. Taylor and some other conservatives have said that if the Fed had followed his rule in the early 2000s, all would be well today. There's no way of knowing if this is true, but it's hard to see how it could have led to a worse outcome than...