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Scientists think rapamycin's cellular target - called mTOR for "mammalian target of rapamycin" - helps regulate the body's response to nutrients and may also, according to Strong, "gear up responses to stress," such as the oxidative stress that damages proteins and DNA and contributes to disease development. "What we're doing with rapamycin," Strong says, "is we're actually tricking the cells into thinking that they're depleted of nutrients. Rather than the animals losing weight - we haven't noticed any weight loss - they may be just using their proteins more efficiently, and then repairing proteins more efficiently...

Author: /time Magazine | Title: What Does Life-Extending Drug Mean for Humans? | 7/9/2009 | See Source »

...part of it ... if we went back to the concept of shock and awe, those are designed to shock command and control systems. And nations. You can shock and awe human beings, but it doesn't last. I've seen operations where kinetic strikes would go in on a target, and the enemy would come out shooting. They weren't awed...

Author: /time Magazine | Title: TIME's Interview with General Stanley McChrystal | 7/8/2009 | See Source »

Those numbers could be used by governments to establish a pathway for future emissions reductions. Suppose, for example, we wanted to hit a global emissions target of 30 billion metric tons of CO2 in 2030, or about a 30% cut from the business-as-usual forecast of 42 billion metric tons. That would translate to a global individual emissions cap of 10.8 metric tons of CO2, which 1.13 billion people - less than 15% of the global population in 2030 - would exceed. Emissions-reduction efforts would focus on the well-off people above the cap, whatever country they live in. That...

Author: /time Magazine | Title: Study: A Fairer Way to Cut Global CO2 Emissions | 7/7/2009 | See Source »

...financial innovation has turned out to be awfully hard, so in recent years believers in an automated Fed have turned to an equation concocted by Stanford economist John Taylor that takes in inflation, current economic growth and long-term-trend growth and churns out a suggested Fed interest-rate target. Taylor and some other conservatives have said that if the Fed had followed his rule in the early 2000s, all would be well today. There's no way of knowing if this is true, but it's hard to see how it could have led to a worse outcome than...

Author: /time Magazine | Title: Dumbing Down Regulation: The Quest For Simpler Rules | 7/6/2009 | See Source »

...most extreme circumstances - a turnabout for U.S. ground forces that have grown dependent on air support. McChrystal has also declared - in a soon-to-be-released tactical directive - that soldiers should hold their fire if there is even the slightest risk of a civilian presence in the target zone. "Suppose the insurgent occupies an enemy home or village and engages you from there with the clear idea that when you respond, you are going to create collateral damage," explains McChrystal. "He's going to blame that on you. Even if you kill the insurgents, what happens is you have made...

Author: /time Magazine | Title: Why Obama's Afghan War Is Different | 7/5/2009 | See Source »

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