Word: targetting
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Dates: during 1990-1999
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...problem is that the altered viruses do not always seek out the target cells and sometimes insert themselves in the wrong place in the cellular DNA. Then too, once in place, the new genes sometimes fail to express themselves. "There are still a few walls to get over," Anderson concedes. He points out that in the initial trial, viruses used for cystic fibrosis, for example, produced an inflammatory response: "So the trials were halted, and another generation of viral vectors was developed. Now we're going to restart the clinical trials with these new-generation vectors," which he thinks will...
Useful as they are, these drugs share the same serious drawback. Because they target all dividing cells, they also kill off normal tissue in the skin, hair and bone marrow. The next generation of anticancer agents, however, promises to be much more selective. By targeting oncogenes, for example, researchers hope to switch off the signals that prompt cancer cells to divide in the first place. Particularly promising is a class of drugs known as farnesyltransferase inhibitors, which have been shown to shrink tumors while sparing normal tissues. "Oncology is not a profession that inspires optimism," admits Dr. Allen Oliff, director...
...security arguments for 24-hour access for all students in every house should now be familiar: universal access would make propping doors for friends from other houses obsolete and would make students more hesitant to mindlessly admitting those without an ID of their own; it would remove the easy target of a student waiting alone for someone to come out of a house so that they would be able to enter...
...U.A.W.'s real target is GM, which is under pressure from Wall Street to cut an additional 30,000 to 50,000 jobs--or up to 20% of its remaining U.S. hourly payroll--over the next three years. To do that, GM wants to buy more auto parts from outside suppliers. The No. 1 automaker uses in-house labor to build a whopping 70% of the parts that go into its vehicles, far more than its Detroit rivals. But the U.A.W. wants to save as many jobs as it can at GM, which could make the talks turn bitter...
...than 450 U.S. corporations. Even the Coors Brewing Co.--long associated with a right-wing, antigay agenda thanks to Coors family members' generous support of the Heritage Foundation and the Free Congress Foundation--began offering gay partners the same benefits as spouses in 1995. Coors had previously been the target of boycotts by gay-rights groups, but claims it changed its policy simply because, in the words of spokesman Joe Fuentes, "Peter Coors [Joseph's son] said, 'It's the right thing...