Word: taxol
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...Edwards' original cancer was diagnosed in the fall of 2004. The specifics of her treatment were not made public, but doctors say it's likely that, in addition to surgery and radiation, she's already received three of the most commonly used drugs - Adriamycin, Cytoxan and either Taxol or Taxotere. This potent regimen knocks out tumor cells and causes the familiar side effects of nausea and hair loss. If her original tumor was estrogen-sensitive - meaning growing in response to the hormone - then she is almost certainly taking an estrogen-blocking drug such as Tamoxifen. (See TIME's photo-essay...
Keasling, 41, has spent the past 13 years at the University of California, Berkeley, working out how to trick E. coli microbes into churning out synthetic and beneficial versions of plant products. He was particularly interested in molecules known as terpenoids, like artemisinin, which treats malaria; taxol, an anticancer drug; and prostratin, a potential anti-HIV compound...
Keasling's next project is to begin adapting his technology to produce taxol, prostratin and maybe even new sources of energy and ways to clean up the environment. "I guess when I go to my grave, I'd like to have helped come up with solutions for some of society's most significant problems," he says. Thank goodness he never liked those pigs...
...researcher. He has been investigating--along with my oncologist, Dr. Roger Keresztes, also at Weill--whether COX-2 inhibitors have a role in making treatment more effective and in keeping the disease at bay. Celebrex would be taken during the chemotherapy phase of treatment--in my case, Taxol and Carboplatin. After chemo, I was to take 800 mg of Celebrex (that's two to four times the normal dose) for two years. Oh, yes, there would be nine hours of surgery to remove the offending esophagus. With this cancer, you get the full sushi...
...Mack of Florida, summed it up: "The Federal Government, mainly through the NIH, funds about 36% of all U.S. medical research ... Of the 21 most important drugs introduced between 1965 and 1992, 15 were developed using knowledge and techniques from federally funded research." A GAO report last year on Taxol, which had worldwide sales of $6.2 billion from 1998 to 2002, noted, "Through a collaboration with NIH, [Bristol-Myers Squibb] benefitted from substantial investments in research conducted or funded by NIH." The collaboration "provided the company with research results that enabled [Taxol] to be quickly commercialized...