Word: tb
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Dates: during 2000-2009
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What has happened instead, says Zhenkun Ma, head of research at the Global Alliance for TB Drug Development, who was not involved in the new study, is that "we use really old drugs to fight a very new disease. TB evolves every day." So do all other bacteria. Increasingly, the old arsenal of antibiotics is losing power...
Ebright hopes myxopyronin will be especially useful in the battle against drug-resistant tuberculosis, a disease for which clinicians have never had a perfect therapy. The success of TB treatment depends on the destruction of active and dormant bacteria to prevent relapse - something that few existing antibiotics have been able to do. One way to kill a dormant cell is to target biochemical processes that continue even in latency - there aren't many of those. But myxopyronin works by interfering with the enzyme RNA polymerase, which controls gene transcription in cells and is necessary for cell survival, dormant...
...Face of Tuberculosis Your poignant, powerfully illustrated piece on tuberculosis reminded me of pictures from history books about the 1918 Spanish-flu outbreak [Oct. 13]. Why is the world still ignoring this deadly disease? Thank you, TIME, for reminding us that TB should be a greater medical priority than advances in cosmetic surgery. I hope the pharmaceutical industry can engineer new drugs against this killer. Aniee Sarkissian, Glendale, California...
Your poignant, powerfully illustrated piece on tuberculosis reminded me of pictures from history books about the 1918 Spanish-flu outbreak [Oct. 13]. Why is the world still ignoring this deadly disease? Thank you, TIME, for reminding us that TB should be a greater medical priority than advances in cosmetic surgery. I hope the pharmaceutical industry can engineer new drugs against this killer. Aniee Sarkissian, GLENDALE, CALIF...
Over the past five months, TIME's James Nachtwey has documented the resurgence of TB in seven countries. Turning back the epidemic will require not just newer and more effective drugs but also better ways to detect the disease and a renewed commitment to expanding existing TB-treatment programs. In June the World Health Organization (WHO) recommended a new, rapid test for TB that can provide results in as little as two days. But for most TB-ravaged nations, adopting the technique will require upgrading lab facilities. That's not easy, but it's something WHO hopes will ultimately help...