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...Japan, tuberculosis researchers have developed a form of BCG vaccine that resists tropical heat. In a major test in Madras, WHO teams are treating TB victims with isoniazid (TIME, March 2, 1962) and are searching for another, equally inexpensive drug to combine with isoniazid to keep down resistant bacilli...

Author: /time Magazine | Title: Medicine: Doctor to the World | 6/1/1962 | See Source »

Soup of Life. The underfed peasants succumb easily to TB, gastroenteritis and chistosoma, a debilitating liver parasite that infects one-fifth of the rural population. Average life expectancy in Brazil's Northeast is 30 years, and in Rio Grande do Norte, 463 of every 1,000 babies die in their first year. Most infants are fed a diet of manioc flour mixed with molasses, never taste milk and sometimes do not even get enough water. In Cruz de Armas, a village in Paraiba, the government operates an infant "rehydration station," which dispenses a watery soup to hundreds of children...

Author: /time Magazine | Title: Brazil: The Hungry Land | 5/18/1962 | See Source »

...greatest single killer in the U.S. in 1900 (39,000 deaths in a population of 76 million), TB dropped by 1950 to seventh rank (34,000 deaths in a population of 151 million). Doctors still do not know all the reasons for this happy decline, but they do know what happened next. Isoniazid, first synthesized in Prague in 1912 and then forgotten, was rediscovered simultaneously by three groups of chemists (two in the U.S.). By 1960, despite the population boom, TB deaths dropped to 10,500. New TB cases reported fell from...

Author: /time Magazine | Title: Medicine: TB: Ten Years After | 3/2/1962 | See Source »

Patients must take the little white isoniazid pill three times a day with meals, for at least a year after their disease is arrested. Members of a TB victim's immediate family should also take isoniazid, especially youngsters with a positive tuberculin test reaction. The cost, never great, is now down to $1.50 per 100 pills for private patients; and health agencies, which distribute most of the pills free, can get them for as little...

Author: /time Magazine | Title: Medicine: TB: Ten Years After | 3/2/1962 | See Source »

Resistant Strains. One early fear about isoniazid has been justified: from 3% to 6% of new TB cases are caused by isoniazid-resistant bacilli. But the multiplication of these resistant strains can usually be checked by giving isoniazid with a second drug (streptomycin, para-aminosalicylic acid or cycloserine), and occasionally switching the combination...

Author: /time Magazine | Title: Medicine: TB: Ten Years After | 3/2/1962 | See Source »

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