Word: tepper
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Dates: during 2000-2009
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...make this search as easy as possible, Millennium chief scientific officer Dr. Robert Tepper has chosen to focus on the low-hanging fruit--going first for the most obvious targets. In looking for anticancer drugs, for example, his researchers are concentrating on monoclonal antibodies, a type of biological "smart bomb" that targets cancer cells and leaves normal cells alone. Like all antibodies, these man-made cancer missiles seek out particular receptors--molecules on the cancer cell's surface that help the cell recognize and react to nearby enzymes and proteins. Almost a dozen such drugs are already on the market...
...absorbed by the body and that they won't have toxic side effects. Some of these studies can be done in the lab, but they quickly move into animal and finally human subjects. Already, Millennium has 40 potential targets for monoclonal-antibody drugs against various cancers, and Tepper's goal is to generate 10 to 12 new ones each year...
...Tepper's team used this reasoning to try to improve on the popular blood-pressure-lowering drugs known as ACE inhibitors. These compounds inhibit an enzyme called angiotensin-converting enzyme (ACE), which is responsible for making the muscle cells in blood vessels contract, which drives blood pressure up. By interfering with the activity of this enzyme, ace inhibitors keep blood vessels relaxed and pressure down...
Phyllis Raffall and Irving Tepper hoped their 1967 marriage would bring an end to the pain each had suffered: Phyllis' first husband had died at age 36 of a heart attack, and Irving's first wife had left him for another man. It didn't turn out quite that...