Word: teropterin
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...worth, and then some. They bickered over whether Ruth really knew that he had cancer of the throat, or had merely known -since the last rites of the Roman Catholic Church were administered July 21-that he was bound to die; they told conflicting stories about whether Teropterin had been used to treat him. They quoted the priest who blessed the Babe ("He died a beautiful death"). They quoted or put quotes into the mouths of moppets who hung around the hospital ("Urchins from nearby brownstone houses and cold-water flats," sniffled the Daily Mirror, "huddled in the dark outside...
...Indian-born physiologist and biochemist, director of research for the Lederle Laboratories (American Cyanamid Co.); in Pearl River, N.Y. As a Harvard graduate student, he pioneered in studies on muscular contraction, after going to Lederle concentrated on folic acid (part of the vitamin-B complex), helped develop its derivatives, teropterin and aminopterin (now being used to fight cancer), directed research that produced the new antibiotic, aureomycin (a cure for serious infections untouched by penicillin or streptomycin...
...drug, called Teropterin, was developed by the Lederle Laboratories, and was first tried on animals and one patient at Mt. Sinai Hospital (TIME, Sept. 15). It is a vitaminlike chemical derived from folic acid...
Doctors do not know exactly how it works. Some hope that Teropterin is the kind of material that researchers have long sought as the most likely means of fighting cancer: a substance so similar to a cancer cell's favorite food that the cell devours it, but so devoid of nourishment that the cell starves. Dr. Lehv & colleagues are drawing no sweeping conclusions as to how effective Teropterin is against cancer; but none of the doctors doubts its effectiveness as a pain-reliever...
Lederle Laboratories, whose chemists are extraordinarily hopeful about Teropterin, has invested millions in developing the drug, and has recently begun to distribute it to hospitals for clinical tests. It is much too soon to get excited about Teropterin as a "cure," Dr. Lehv cautioned. The Harlem Hospital group has used the new drug only three months, found that some types of cancer seemed to respond better than others. But researchers who know about Teropterin's performance thus far think that the drug promises at least one great gain in the anti-cancer war: it seems likely to relieve...
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