Word: tetanus
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Dates: during 1940-1949
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Lina Stern's specialty is the physiology of the brain and central nervous system. U.S. doctors who have studied her solid, imaginative work agree that her discoveries may well be a milestone in the treatment of shock, tetanus, high blood pressure and many other disorders involving the central nervous system. Her method differs in technique and purpose from intraspinal injections used...
Around the Filter. For a long time, Dr. Stern worried over a basic medical problem: why is it that certain medicines and serums injected into the blood stream do not get through to the brain nerve centers? Intravenous injections of anti-tetanus serum, for example, fail to check tetanus once the poison gets into the central nervous system. Dr. Stern decided that there must be a barrier (a filtering membrane), developed to protect the nerves and spinal fluid from harmful substances and most germs. She called this block the "hematoencephalic barrier...
...Stern proceeded to try brain injections (of vitamins, sedatives, medicines, etc.) for many other ailments, got good results against tetanus, ulcers, skin diseases, inflammation of the brain, insanity...
Infrequent emergency situations also trouble the medical students. One child entered the clinic one day with a rusty nall in his foot. Though anti-tetanus serum was necessary, the students are not permitted by law to administer it. Thus the problem of getting in touch with busy neighborhood doctors, or of supplying funds for hospital transportation arose. Though this problem was solved, it is the kind of perplexing situation that confronts the "medics" occasionally, Cobb said...
Following up this lead, the two Russian researchers tried other toxins. Two-diphtheria and tetanus-seemed to work. Tested on cancerous mice, tetanus toxin checked or reduced tumors in half the cases. Diphtheria toxin did even better: out of 65 mice with cancers, it cured 39, stopped tumor growth in 19. Unlike KR, the toxins have still to be tested on humans. U.S. researchers, fascinated but uncertain, are pursuing experiments along similar lines...