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Dates: during 2000-2009
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A team led by Harvard researchers has discovered a family of naturally occurring proteins in human cells that protect against influenza and other illnesses—a finding that may lead to methods to speed up vaccine production and to new flu prevention drugs for humans.
Shedding greater light on the human body’s first-line defense against the flu virus, the researchers found that the family of flu-fighting proteins—called the interferon-inducible transmembrane (IFITM) proteins—prevented or slowed down most virus particles from infecting human cells early...
“Most of the time we find things that the virus needs,” said Abraham L. Brass, instructor in medicine at Harvard Medical School and Mass. General Hospital, who helped lead the study. “This time we found something our cells are using to...
The influenza virus—equipped with only eight genes of its own—hijacks the genetic material of its host cell, infecting and utilizing the human genes to execute the virus’ own operations, according to Stephen J. Elledge, a professor of genetics at Harvard Medical School...
The researchers, who had already used this same process in studies of HIV and the hepatitis C virus, hoped to find that some of the treated cells could not be infected with the influenza virus, which would suggest that the virus needed the deactivated gene to function. Instead, the researchers...