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Dates: during 2000-2009
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The latest study of an Australian H1N1 vaccine, a shot that is also distributed in the U.S., shows that a single dose containing the same amount of viral protein as two doses combined, can produce enough flu-fighting antibodies in nearly 93% of youngsters immunized. "The single-dose response is...
In the study, which involved 370 healthy children ages six months to nine years in Australia, researchers immunized half of the group with two doses of vaccine, each containing 15 micrograms (mcg) of the virus antigen. The other half received two doses containing 30 mcg of the antigen each. In...
The results suggest that one shot of the lower-dose vaccine may generate just as many flu antibodies as the two shots U.S. children currently receive, each containing 7.5 mcg of viral antigen. The findings could factor into discussions that health officials have as they make up recommendations for next...
But until then, neither Nolan nor officials at the Centers for Disease Control and Prevention (CDC) are ready to ditch the second dose. For one thing, they note, the level of antibodies does not always translate to actual protection against the flu. "Lab studies are a proxy and work well...
Another reason to be cautious about the Australian data, says Fiore, is that the youngsters in the study were all healthy, with normal immune systems. But those who are most vulnerable to influenza are children with underlying conditions such as asthma or diabetes, who may need the added boost from...