Word: thousands
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Dates: during 2000-2009
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...Diego, Calif., for example, has zeroed in on the interactions between helper T cells and APCs to develop antibody drugs against lupus and RA. Their anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has developed a drug that works by blocking Interleukin-1, another molecule that promotes inflammation...
Currently, Guilford Pharmaceuticals in Baltimore and Amgen in Thousand Oaks, Calif., are collaborating on a synthetic neurotrophic compound that can be taken orally and then travel to the brain, where it bonds with proteins in dopamine neurons. The tricky part is that most trophic molecules are too big to cross the blood-brain barrier, so Guilford and Amgen are working on a smaller one that can get where it needs to go. The progress so far is promising. "We’re in phase two human trials and the study is going very well," says Dr. Craig Smith...
...million cars and trucks sold yearly in the U.S., it is a modest beginning. A major obstacle: the price trade-off for being green. Savings at the pump--magnified by this year's gasoline-price jumps--are offset by the $20,000 cost of either car. That's several thousand dollars more than similar-size conventional models. If proposed federal tax incentives--pushed by an unusual alliance of automakers and environmentalists--ultimately pass, "there could be a hybrid in every garage," says Roland Hwang, a transportation expert with the Natural Resources Defense Council. That is surely a green dream...
Take DeLong's experience, multiply it a few thousand times in schools across the state, and it isn't surprising that at her campus this year, the freshman class is nearly 61% female. In a freshman English tutorial, small clusters of men sit quietly as women dominate class discussions. But outside class, the mood on campus is distinctly male friendly. Tyler Willingham, social chair of the Sigma Nu fraternity, observes that at parties, even guys without dates can choose from "many beautiful women...
...provincial chateau, in a round tower lined with books, Montaigne wrote the "Essais," his candid, quirkish, sometimes embarrassingly intimate portrait of himself. It was hardly an ivory tower: War and plague and fanaticism swirled around it. A thousand times, Montaigne wrote, he went to bed expecting to be murdered...