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...thus that I have been entrusted with the dubious honor of writing the last Crimson column of the true millennium, a column whose subject is at the same time pre-determined and obsolete, a column of exactly one thousand words that will drop instantly from our printing press to our archives to blessed obscurity, as no one reads The Crimson on the last day before Winter Break. (Including...
...Fleury, on the 19th day of December, in the Year of Our Lord One Thousand, in the 14th indiction...
...Diego, Calif., for example, has zeroed in on the interactions between helper T cells and APCs to develop antibody drugs against lupus and RA. Their anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has developed a drug that works by blocking Interleukin-1, another molecule that promotes inflammation...
Currently, Guilford Pharmaceuticals in Baltimore and Amgen in Thousand Oaks, Calif., are collaborating on a synthetic neurotrophic compound that can be taken orally and then travel to the brain, where it bonds with proteins in dopamine neurons. The tricky part is that most trophic molecules are too big to cross the blood-brain barrier, so Guilford and Amgen are working on a smaller one that can get where it needs to go. The progress so far is promising. "We’re in phase two human trials and the study is going very well," says Dr. Craig Smith...
...provincial chateau, in a round tower lined with books, Montaigne wrote the "Essais," his candid, quirkish, sometimes embarrassingly intimate portrait of himself. It was hardly an ivory tower: War and plague and fanaticism swirled around it. A thousand times, Montaigne wrote, he went to bed expecting to be murdered...