Word: thyroid
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Some types of thyroid cancer do not respond to this treatment. The cells cannot be trained to take up iodine and kill themselves. But many patients have been helped to some extent. In four of them the disease has been definitely checked, though not wiped out entirely...
...good example of the interaction of research and clinical study is the work of Rawson's group and of Dr. L. D. Marinelli on the treatment of thyroid cancer with radioactive iodine. Since the thyroid gland eagerly absorbs iodine (which it uses to make a hormone), doctors have hoped that a cancerous thyroid would absorb radioactive iodine 131 in sufficient quantity to kill the unruly cells. Unfortunately, this effort was none too successful. The normal thyroid took up nearly all the iodine. The cancerous thyroid cells, particularly the metastases in distant parts of the body, took up so little...
Trained Metastases. Dr. Marinelli and his associates worked out a neat method of dealing with this difficulty. First they removed the patient's normal thyroid and with it the original cancer. This left the metastases which, they found, often consisted of cancer cells that retained faint remnants of the normal function of the thyroid. With the normal thyroid gone, the degenerate cells awoke and began to act like thyroids. Stimulated by the proper drugs, they began taking up iodine and making it into thyroid hormones. Then Dr. Marinelli gave radioactive iodine to the patient. The tumors, acting as pinchhitting...
...Hertz was born in Cleveland and is a graduate of the Harvard Medical School Class of 1929. After an internship and residency in Medicine at Mt. Sinal Hospital in Cleveland, he returned to Boston and has been active in research in thyroid disease since 1931. He has contributed numerous scientific articles in endocrinology and is a member of the Society for Clinical investigation and the Federation of Experimental and Biological Societies. He is also a member of Phi Beta Kappa. He has been on the staff of the Massachusetts General Hospital and was in charge of the Thyroid Clinic until...
...even more fundamental forms of treatment of Grave's disease. However, he emphasized this example in therapeutic application as a beacon in utilizing the tracer methods employing radioactive substances for the analysis of cellular function, growth, metabolism and nutrition in the body and in other organs than the thyroid. He pointed out that knowledge gained about the thyroid has already led him and others to many stimulating theories in the cancer and enzyme fields...